If you are running 4.6C, there is no need to put the contents of the application help CD on servers across the globe or play about with sapdoccd.ini, just point everyone towards the Internet.
In tcode SR13, enter the following under the tab PlainHtmlHelp (2nd one from left)
Variant - Internet
Platform - Win32 (use this for NT4.0 or higher)
Area - IWBHELP
Server Name - help.sap.com
Path - saphelp_46c/helpdata
Language - EN
Default - Check box
We found that for some transactions (GRR3), application help was not available on the CD for the April 2001 version. However, the same version on the Internet did have the application help.