There are different techniques you can use to do this and some of these techniques depend on the R/3 version you're running. However, the most common way is through a CATT (transaction SCAT). This link http://www.sap-img.com/sap-catt.htm should take you to a guideline on how to create your first CATT.
You will need to a tab-delimited file or a spreadsheet with all the user names you want to create, of course. But, once you get the hang of it, you'll be able to save a lot of precious time.
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