EXPERT RESPONSE
The AS/400 is indeed known to be extremely robust. Windows with SQL Server (especially the 64-bit version) is also very stable, however. I was involved in several migration projects in which customers went from "you name it" to SQL Server. Some of them came from AS/400. Also, several customers of mine run databases with several hundreds of GBs up to two TBs on SQL Server. These systems run 24 by 7.
In the migration projects in which I was involved, the same system administrators still support the environment as they did before the migration. A transition period was needed, however, during which everyone had to get to know the new environment.
The best thing to do in order to compare the needed resources, would be to contact several hardware vendors. They can easily size a target environment based on an Early Watch Session conducted on the current environment. In addition, the OS/DB Migration Service from SAP verifies the source and suggests modifications to the target environment before the go-live, in order to avoid the unexpected.
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